Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC058
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-09-28 12:38
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment New patient

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 29 individuals with a value less than 0.62 were subsequently diagnosed with PD. That is, 69.05% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.62 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 22, 'TN': 17, 'TP': 20, 'FP': 13}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 26, 'TN': 22, 'TP': 16, 'FP': 8}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 41, 'TN': 30, 'TP': 1, 'FP': 0}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 9, 'TN': 7, 'TP': 33, 'FP': 23}

Test Battery Details

Circle

numCircles 7
timePerCircleMean 38.8914
timePerCircleCoV 0.308635
timePerCircleSlope -0.126249
meanError 1.85131
tremorFreq 5.46875
tremorRelPower 44.1769
tremorGyroAmpMean 0.0313827
tremorGyroAmpSlope 0.00276868
tremorGyroAmpCoV 0.45509
tremorCoordAmpMean 0.0427503
tremorCoordAmpSlope 0.00285721
tremorCoordAmpCoV 0.470643
tremorAccAmpMean 0.0417456
tremorAccAmpSlope 0.00296243
tremorAccAmpCoV 0.42237
tremorPcRelVar 0.723574
tremorPcX 0.613391
tremorPcY -0.789779

Circle Segment 1

Duration 46.76 s, Accuracy Estimate 2.223 (lower is better)

Circle Segment 2

Duration 58.2 s, Accuracy Estimate 2.342 (lower is better)

Circle Segment 3

Duration 39.88 s, Accuracy Estimate 1.279 (lower is better)

Circle Segment 4

Duration 43.2 s, Accuracy Estimate 1.295 (lower is better)

Circle Segment 5

Duration 34.32 s, Accuracy Estimate 1.885 (lower is better)

Circle Segment 6

Duration 24.88 s, Accuracy Estimate 1.682 (lower is better)

Circle Segment 7

Duration 25.0 s, Accuracy Estimate 2.255 (lower is better)

Spiral

numSpirals 5
timePerSpiralMean 49.016
timePerSpiralCoV 0.422805
timePerSpiralSlope -0.126571
meanError 2.13224
tremorFreq 5.27344
tremorRelPower 34.6995
tremorGyroAmpMean 0.0367638
tremorGyroAmpSlope 0.00234899
tremorGyroAmpCoV 0.468947
tremorCoordAmpMean 0.0523318
tremorCoordAmpSlope 0.0018978
tremorCoordAmpCoV 0.474678
tremorAccAmpMean 0.04728
tremorAccAmpSlope 0.00183564
tremorAccAmpCoV 0.454222
tremorPcRelVar 0.625184
tremorPcX -0.731164
tremorPcY -0.682201

Spiral Segment 1

Duration 52.4 s, Accuracy Estimate 1.478 (lower is better)

Spiral Segment 2

Duration 52.8 s, Accuracy Estimate 2.527 (lower is better)

Spiral Segment 3

Duration 58.04 s, Accuracy Estimate 2.416 (lower is better)

Spiral Segment 4

Duration 68.12 s, Accuracy Estimate 2.264 (lower is better)

Spiral Segment 5

Duration 13.72 s, Accuracy Estimate 1.977 (lower is better)

Elel

eDurationMean 0.782571
eDurationStd 0.341397
eDurationStdnorm 0.43625
eDurationMedian 0.685
eDurationQuartdelta 0.18375
eDurationQuartdeltanorm 0.268248
eDurationKurt 15.2469
eDurationTrenddiff -0.13
eDurationTrendratio 0.831169
eWidthMean 3.81086
eWidthStd 1.26532
eWidthStdnorm 0.332031
eWidthMedian 3.627
eWidthQuartdelta 1.37475
eWidthQuartdeltanorm 0.379032
eWidthKurt 5.77064
eWidthTrenddiff 0.702
eWidthTrendratio 1.22222
eHeightMean 7.64177
eHeightStd 1.9936
eHeightStdnorm 0.260882
eHeightMedian 7.02
eHeightQuartdelta 2.83725
eHeightQuartdeltanorm 0.404167
eHeightKurt 2.61779
eHeightTrenddiff -1.989
eHeightTrendratio 0.760563
eAspectMean 0.515354
eAspectStd 0.151543
eAspectStdnorm 0.294056
eAspectMedian 0.518987
eAspectQuartdelta 0.205613
eAspectQuartdeltanorm 0.396181
eAspectKurt 2.27149
eAspectTrenddiff 0.153529
eAspectTrendratio 1.36555
eSlantMean -0.0274339
eSlantStd 0.176236
eSlantStdnorm -6.42403
eSlantMedian -0.0208333
eSlantQuartdelta 0.244669
eSlantQuartdeltanorm -11.7441
eSlantKurt 2.91723
eSlantTrenddiff 0.10383
eRtopMean 0.651993
eRtopStd 0.156015
eRtopStdnorm 0.239289
eRtopMedian 0.64
eRtopQuartdelta 0.170601
eRtopQuartdeltanorm 0.266565
eRtopKurt 2.43277
eRtopTrenddiff 0.0523077
eRbotMean 0.754638
eRbotStd 0.34776
eRbotStdnorm 0.460831
eRbotMedian 0.681159
eRbotQuartdelta 0.487081
eRbotQuartdeltanorm 0.715077
eRbotKurt 6.39086
eRbotTrenddiff -0.115468
eRrightMean 0.832016
eRrightStd 0.0890875
eRrightStdnorm 0.107074
eRrightMedian 0.851064
eRrightQuartdelta 0.127743
eRrightQuartdeltanorm 0.150098
eRrightKurt 2.64375
eRrightTrenddiff 0.0434174
eRleftMean 0.451782
eRleftStd 0.167835
eRleftStdnorm 0.371495
eRleftMedian 0.408451
eRleftQuartdelta 0.270632
eRleftQuartdeltanorm 0.662581
eRleftKurt 1.87532
eRleftTrenddiff -0.0357143
lDurationMean 1.09133
lDurationStd 0.634154
lDurationStdnorm 0.581082
lDurationMedian 1.0325
lDurationQuartdelta 0.47
lDurationQuartdeltanorm 0.455206
lDurationKurt 9.08133
lDurationTrenddiff -0.16
lDurationTrendratio 0.857143
lWidthMean 3.5061
lWidthStd 0.761653
lWidthStdnorm 0.217236
lWidthMedian 3.4515
lWidthQuartdelta 0.702
lWidthQuartdeltanorm 0.20339
lWidthKurt 3.16277
lWidthTrenddiff 0.117
lWidthTrendratio 1.03448
lHeightMean 14.2701
lHeightStd 3.30276
lHeightStdnorm 0.231446
lHeightMedian 14.4495
lHeightQuartdelta 3.978
lHeightQuartdeltanorm 0.275304
lHeightKurt 4.41941
lHeightTrenddiff -1.872
lHeightTrendratio 0.881481
lAspectMean 0.2628
lAspectStd 0.119763
lAspectStdnorm 0.455717
lAspectMedian 0.237936
lAspectQuartdelta 0.0769401
lAspectQuartdeltanorm 0.323365
lAspectKurt 16.0173
lAspectTrenddiff -0.0102964
lAspectTrendratio 0.958433
lSlantMean -0.0376708
lSlantStd 0.11463
lSlantStdnorm -3.04293
lSlantMedian -0.0166931
lSlantQuartdelta 0.11113
lSlantQuartdeltanorm -6.65726
lSlantKurt 5.68689
lSlantTrenddiff 0.0382957
lRtopMean 0.694882
lRtopStd 0.140703
lRtopStdnorm 0.202484
lRtopMedian 0.707143
lRtopQuartdelta 0.214809
lRtopQuartdeltanorm 0.303771
lRtopKurt 2.09403
lRtopTrenddiff -0.01875
lRbotMean 0.859988
lRbotStd 0.400253
lRbotStdnorm 0.465418
lRbotMedian 0.75
lRbotQuartdelta 0.3118
lRbotQuartdeltanorm 0.415734
lRbotKurt 5.33744
lRbotTrenddiff -0.152218
lRrightMean 0.85767
lRrightStd 0.0967898
lRrightStdnorm 0.112852
lRrightMedian 0.902627
lRrightQuartdelta 0.159688
lRrightQuartdeltanorm 0.176914
lRrightKurt 2.17156
lRrightTrenddiff -0.0632962
lRleftMean 0.321065
lRleftStd 0.141618
lRleftStdnorm 0.441088
lRleftMedian 0.307778
lRleftQuartdelta 0.196913
lRleftQuartdeltanorm 0.639788
lRleftKurt 3.08736
lRleftTrenddiff -0.0795833

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

Elel Segment 11

Elel Segment 12

Elel Segment 13

Elel Segment 14

Elel Segment 15

Elel Segment 16

Elel Segment 17

Elel Segment 18

Elel Segment 19

Elel Segment 20

FITTS Short Modified

meanTouchScore 0.968545
sumTouchScores 9.68545
meanMovementTime 1.51889
numTouches 10
undershootPercentage 0
overshootPercentage 0

FITTS Long Modified

meanTouchScore 0.887168
sumTouchScores 9.75884
meanMovementTime 1.5875
numTouches 11
undershootPercentage 0
overshootPercentage 18.1818

fitts_long data not in signals file.

ZigZag

numZigzags 3
timePerZigzagMean 56.6933
timePerZigzagCoV 0.172813
timePerZigzagSlope -0.125941
meanError 1.84827
tremorFreq 5.07812
tremorRelPower 35.5011
tremorGyroAmpMean 0.0634578
tremorGyroAmpSlope 0.000353698
tremorGyroAmpCoV 0.659566
tremorCoordAmpMean 0.0907093
tremorCoordAmpSlope 0.00024868
tremorCoordAmpCoV 0.729828
tremorAccAmpMean 0.0603538
tremorAccAmpSlope -0.000503405
tremorAccAmpCoV 0.443222
tremorPcRelVar 0.754624
tremorPcX -0.0295352
tremorPcY 0.999564

ZigZag Segment 1

Duration 59.96 s, Accuracy Estimate 2.084 (lower is better)

ZigZag Segment 2

Duration 64.44 s, Accuracy Estimate 2.032 (lower is better)

ZigZag Segment 3

Duration 45.68 s, Accuracy Estimate 1.429 (lower is better)

ZigZag Offset

numZigzags 4
timePerZigzagMean 23.92
timePerZigzagCoV 0.0528633
timePerZigzagSlope 0.0324415
zigzagHeightMean 71.3686
zigzagHeightCoV 0.0566784
zigzagHeightSlope 0.0158557
meanError 0.107294
tremorFreq 5.66406
tremorRelPower 32.4652
tremorGyroAmpMean 0.0551107
tremorGyroAmpSlope 0.00279443
tremorGyroAmpCoV 0.381033
tremorCoordAmpMean 0.0956515
tremorCoordAmpSlope 0.00206405
tremorCoordAmpCoV 0.749538
tremorAccAmpMean 0.100031
tremorAccAmpSlope 0.00118778
tremorAccAmpCoV 0.174819
tremorPcRelVar 0.855375
tremorPcX -0.412255
tremorPcY -0.911069

ZigZag Offset Segment 1

Duration 23.12 s, Accuracy Estimate 0.121 (lower is better)

ZigZag Offset Segment 2

Duration 23.52 s, Accuracy Estimate 0.118 (lower is better)

ZigZag Offset Segment 3

Duration 23.24 s, Accuracy Estimate 0.083 (lower is better)

ZigZag Offset Segment 4

Duration 25.8 s, Accuracy Estimate 0.107 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.9}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.62}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.632577392007325}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.8219901871510364}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.7740070014563843}